Dr. Locksley is a Distinguished Professor in the Department of Medicine at UC San Francisco. He also serves as the Director of the Sandler Asthma Basic Research Center (SABRE) and is a Howard Hughes Medical Institute Investigator. Dr. Locksley’s laboratory pioneered the use of mice genetically engineered to report cytokines expressed during allergic immune responses. Using these methods, the laboratory participated in the discovery of innate lymphoid type 2 cells, or ILC2s, and tuft cells, enigmatic epithelial cells at mucosal surfaces which activate tissue ILC2s and neural regulatory circuits, thus revealing entirely new avenues for discovery. His laboratory currently focuses on innate immunity; the discovery of ILC2s, which are prominently involved in allergy, initiated efforts to uncover the ‘ground state’ of allergy by investigating homeostatic pathways involving these cells to provide insights regarding their primary function in tissue health. He is a member of the Pew Scholars Program Advisory Committee and the Lasker Basic Medical Research Awards Jury. Dr. Locksley is also a member of the American Academy of Arts and Sciences and the National Academy of Sciences.

Dr. Locksley received his undergraduate degree in biochemistry from Harvard and his M.D. from the University of Rochester. After completing his medical residency and chief residency at UCSF, he trained in infectious diseases at the University of Washington.